Endocrine Abstracts

: The observed increase in the incidence of Hashimoto’s thyroiditis (HT) requires research on factors that may affect its development. One of them may be vitamin D deficiency which is an epidemiological problem all over the world.Aim: The assessment of influence vitamin D deficiency on the HT activity.Material and methods: 310 people were enrolled in the study: 155 patients with HT (a-TPO and/or a-TG positivity)-144 women (93%...

Introduction: Undetectable concentration of Tg after rhTSH stimulation (Tg/rhTSH) is one of the most important criteria in evaluating the effectiveness of radioiodine ablation in patients with differentiated thyroid cancer (DTC) treated with 131I.Aim: To evaluate the possibility of using L-T4 suppression treatment (Tg/L-T4) measurements by the ultrasensitive method TRACE (immunofluorescence method) with the KRYPTOR analyzer instead of the Tg/rhTSH measur...

Introduction: Treatment of Graves orbitopathy (GO) is one of the most difficult problems in clinical endocrinology. Objective: To establish the efficacy of the regime used in the treatment of GO and to analyze methods used to determine treatment effectiveness.Material: The study involved 30 patients with moderate to severe GO (according to the classification of EUGOGO) being in the active phase of GO.Method: ...

Background: The activating somatic point mutation, BRAFV600E, is the most common genetic alteration observed in papillary thyroid carcinoma (PTC) but its oncogenic role in PTC has been extensively investigated. Numerous studies reported that BRAFV600E correlates with poor clinical outcome, whereas others have found no such association. It is estimated that BRAFV600E occurs in ~ 45–50% of PTC cases, but recent studies showed the more freque...

Introduction: Postoperative thyroglobulin (TgPO) has a well established position as the prognostic factor for the follow-up of patients with differentiated thyroid cancer (DTC) after total thyroidectomy. However, the presence of thyroid remnants after surgery may diminish predictive value of TgPO.The aim of the study is to evaluate prognostic value of stimulated postablative thyroglobulin level (TgPA) measured after 6–9 months after radioacitve iodi...

Introduction: The correct 25-hydroxy vitamin D (25(OH)D) level plays a key role in the proper supply of vitamin D for the organism. Vitamin D deficiency may lead to an increased risk of development of various neoplasms, including papillary thyroid carcinoma (PTC).Aim: Evaluation of the prevalence of vitamin D deficiency in patients with PTC and analysis of the relation between 25(OH)D levels and age, sex, place of living, severity of the disease, and pre...

The pentagastrin-stimulated calcitonin test is known and widely used in monitoring patients with MTC. Given the problems of pentagastrin availability other diagnostic tests are being tried.The goal of the study was the evaluation of safety and tolerance of high-dose calcium to stimulate calcitonin in MTC patients.Materials: The study included 41 patients after surgery for medullary thyroid cancer who were under observation. Patient...

Introduction: The Pg calcitonin stimulation test is widely used in monitoring patients with MTC. In view of accessibility problems of Pg it is necessary to use high doses of calcium as the calcitonin stimulant.Objective: The aim of the study was the comparison of calcitonin concentrations after Pg and calcium stimulation, respectively.Materials: The study was performed in 31 patients under observation after deemed surgically cured ...

Introduction: Calcitonin is the main MTC marker. However, it has limitations: rapid in vitro degradation, a concentration-dependent biphasic half-life, presence of different isoforms and high cost of a single trial. Other markers of MTC can be procalcitonin and ProGRP.Aim: The aim of the study was to evaluate the diagnostic performance of marking the levels of procalcitonin and ProGRP in monitoring patients with MTC.Material...

Introduction: Case reports of individuals with non-insulinoma hyperinsulinic hypoglcaemia of organic origin has been more frequently described in literature. This syndrome has been described as a rare complication of bariatric surgeries and the term of NIPHS (non-insulinoma pancreatogenic hypoglycemia syndrome) has been proposed.Aim: The aim of our study is to present patients case who had previously undergone the gastric surgery. Bilroth II and finally ...